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Doxycycline is a molecule of the cyclin family that works as an antibiotic by slowing the growth of bacteria in the body. It is a semi-synthetic tetracycline that was developed in the early 60s by Pfizer Inc. and marketed under the name Vibramycin, approved by the FDA in 1967. It was the first broad-spectrum daily antibiotic created and proved to be effective against intracellular bacteria.
After ingestion, it is converted to its active form. The active form of hydroxyzine is a drug called cetirizine (Zyrtec). Although, both hydroxyzine and cetirizine act as antihistamines, hydroxyzine causes more sedation than cetirizine. The FDA approved hydroxyzine in 1956.

 

Tetracycline (INN) is a broad-spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria, indicated for use against many bacterial infections. It is a protein synthesis inhibitor. It is commonly used to treat acne today, and, more recently, rosacea, and played a historical role in reducing the incidence of mortality because of cholera. It is sold under the brand names Sumycin, Terramycin, Tetracyn, and Panmycin, among others.
Amoxicillin is susceptible to degradation by b-lactamase-producing bacteria, and so may be given with clavulanic acid to decrease its susceptibility.

 

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